Beilstein J. Org. Chem.2023,19, 901–908, doi:10.3762/bjoc.19.68
the construction of a range of δ-olefin-containing aliphatic nitriles with (E)-configuration selectivity. This new method features wide substrate scope, mild conditions, and directN–Oactivation.
Keywords: directN–Oactivation; E-selectivity; nitrile synthesis; ring-opening cross-coupling; sulfuryl
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Graphical Abstract
Scheme 1:
Representative nitrile-containing functional materials, drug carriers, and medicines.